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Producing a Mockup In the case of a mockup, you want to use photographs, line drawings, or even a drawing tool to create the layout or the template for your project, and then generate a computer-generated version of the layout. Suppose you have some ideas about what you want to do, but you still need to get a sense of the visual impact. To do this, you can print out your sketches and conduct an online search for pictures of similar projects to get a visual idea of what you can accomplish with your final product. You can also make a realistic model of the project or sketch in 3-D, as described in the section “Drawing in 3-D,” later in this chapter. Photoshop makes it easy to create mockups with photographs, drawings, and other elements on the canvas. You may want to use elements such as “ tags, as discussed in Chapter 9. To create a mockup with a piece of content, select the content and use the `Create Smart Object` command. The system creates the image from the original content and stores it in a separate layer. You can then work with the image as a selection and adjust the layers, as shown in Figure 6-11. You can align the position and size of layers within the Layers panel, or in the Layers panel, click the layer thumbnail and then use the Align and Distribute tabs on the Layers panel to move the layers and adjust their proportions. (See Chapter 1 for more information on layers.) Figure 6-11: A Smart Object created from selected content can be edited in much the same way as any other image layer.

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Elements, by its nature, is a simple program to use, so you can learn Photoshop Elements in a few minutes and feel right at home. Elements also has a great community and is very supportive, with a lot of user guides on the internet. To start using Photoshop Elements, you need to download the image editor to your device. Downloads are available for both Mac and Windows users. All you have to do is choose your preferred OS from the download list. These programs allow you to edit images on the go. This means you can work on a portrait of a friend during a trip, or edit a product brochure without having to install Photoshop. If you own a Chromebook, you can download the Elements Classic app. It’s simple to use and requires fewer resources, so it’s a good fit. The best way to become familiar with Elements is to try it out, and there are free tutorials to find on YouTube, as well as with the program’s support forum. When you’re ready to download your first image editing program, here are 10 best programs to help you edit images on the go. Best tools to edit images on the go Panic is a photo editor that will help you quickly make adjustments in your photos. It’s a free app with a simple design. Have fun with this app. It’s great for making quick adjustments to your selfies and resizing photos. Features A wide variety of graphic tools and effects. Adjustments: You can easily adjust brightness, contrast, colors, and more. Support for RAW, JPEG and PNG files. Support for all devices. You can save your edits in.tga,.eps and.jpg formats. Controls A simple user interface, with a slight gradient design. Text tools: You can type text with different fonts. Image mask tools: Once you’ve selected an area you want to mask, you can erase it and apply some filters to the rest of the photo. You can also add frames. You can preview your images in.png,.psd,.tga,.jpeg and.gif formats. Other features include the ability to send your edits to Instagram, Facebook or Twitter, or save them directly to your own Dropbox. Pros Many options a681f4349e

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Does the timing of endothelin-1 signalling impact upon its vasoconstrictor activity? Endothelin-1 (ET-1) is a potent vasoconstrictor peptide. The time-course of action of ET-1 is complex and varies from 10 s to 10 min. Studies with cultured vascular smooth muscle cells have shown that ET-1 induces changes in the cytoskeleton and cell surface expression of certain proteins but it is not known whether this triggers or delays the signaling events leading to the initiation of contraction. We therefore aimed to investigate the expression of the contractile proteins, to determine which proteins form complexes with endothelial nitric oxide synthase and the availability of some key contractile proteins such as phosphorylated myosin light chain, and finally to investigate whether the presence of ET-1 alters their phosphorylation level during the different phases of action of ET-1. Rat aortic smooth muscle cells were cultured with or without ET-1 for 15, 30, 60 and 120 min at 37 degrees C. Thereafter, the cells were homogenized, total protein was extracted and the expressions of specific proteins were evaluated by immunoblotting. ET-1 rapidly (15-30 min) increased myosin light chain phosphorylation and the amount of calponin. Sarcolemma association of vasoconstrictor receptor kinase (ROCK) with endothelial nitric oxide synthase was observed at 15-30 min. ET-1 also enhanced phosphorylation of the myosin binding subunit of myosin phosphatase (MBS) but had no effect on phosphorylation of myosin light chain phosphatase. Endothelial nitric oxide synthase and ROCK forms a complex that is inhibited by the ET-1-induced phosphorylation of MBS. The early (15-30 min) increase in calponin and ROCK suggests that ET-1-induced contraction is mediated by activation of RhoA/ROCK. The persistent phosphorylation of MBS suggests that this contraction may be sustained and does not require new synthesis of the contractile proteins. A Cautionary Tale About Swift 3.0 – anguirus ====== nallerooth This is a good read, but it’s not true. He didn’t pass a swift

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Ampara people’s massacre The Ampara massacre (හමහර පිවිශවීඩන්), also referred to as the Ampara tragedy, was a mass murder of ethnic Sinhalese citizens in Ampara, Sri Lanka (now part of the Eastern Province), committed by a group of military officers in the late 1970s. According to a Sinhalese newspaper (the Sirasa) the event was the result of racism because of the killing was not perpetrated against members of any other ethnic groups. The government has acknowledged the massacre, but denies that it was racially motivated. The massacre was the subject of the documentary film Survivors’ Story in 1988. Incident Between the late 1970s and early 1980s, the country was in a state of turmoil. In 1977, the Navy Mutiny broke out, and an amnesty was declared in 1980. However, on the eve of the amnesty’s repeal, around 100 ethnic Sinhalese inhabitants of Ampara were brutally killed by a group of military officers. The incident was reported in the English language media as the Ampara massacre, and focused on the cruel manner in which they were killed. The alleged perpetrators were the commander of the Ampara Naval Base, Royal Navy Vice Admiral Hector Trevor Dudley, the commander of the Ampara Garrison, Lieutenant Colonel Walter Prime and the commander of the Colombo Garrison, Colonel George Mior Moringhi. The families of both the victims and the alleged perpetrators were interviewed as part of a Sri Lankan documentary, Survivors’ Story, released in 1988. The survivors’ accounts depicted the incident, with the greatest detail given to the moment when the victims were shot. A number of the victims were civilians and were allegedly targeted for being part of the largely pro-democracy, left-wing group, the All Ceylon Muslim Congress (ACMC). Aftermath The government has acknowledged the massacre, but denies that it was racially motivated. The police report on the incident was issued on 10 October 1978, and the officers who carried out the killings were subsequently court-martialed. The incident was also reported in various Sri Lankan papers, including the Sinhala-language Sirasa. The massacre prompted the Emergency Regulations Ordinance, 1982. The massacre also had implications for the military regime,

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Supported OS: Mac OS X (10.7 – 10.10) Windows (Vista / 7 / 8 / 10) Virtually any modern PC. Drivers: Latest Nvidia drivers are required. Latest ATI or AMD drivers are required. Controls As in normal arcade games, you can use arrow keys to move, space bar to jump, or “X” to fire, as well as the standard “Z” for the grappling hook. If you